Hyal-System ACP is a low molecular weight HA-based gel, stabilized without involving any chemical agent, thanks to the patented ACP (Auto-Crosslinked Polymer) technology, to enable a gradual release of highly pure 200kDa HA (slow-release activity), eliciting a biostimulation response.

It improves skin turgidity and elasticity, giving a rejuvenating effect to the skin. As a result, the skin is firm, elastic and rejuvenated.

CompositionAuto-Crosslinked Hyaluronic Acid 200 kDa
HA Concentration20 mg/ml
TechnologyHA A.C.P. Auto-Crosslinked Polymer Technology®
Injection depthSuperficial, mid or deep dermis is for soft tissue defects
Intralesion dermal planes for hypothrophics scars
EffectBiostimulation / rejuvenation
Presentation1x1 ml prefilled syringe
1x30G 13mm, 1x30G 4mm

The redensifying action of LMW HA provides:

More cells: the 200 kDa HA fraction supports cellular proliferation to provide increased tissue density;

More matrix: increased tissue density stimulates production of cell matrix components;

Rejuvenated skin: hydration, elasticity and tone.


The term biostimulation indicates an activation of the biological functions of the skin in order to optimize its physiology and achieve aesthetic improvement. It requires, among others, the chemical-physical optimization of the extracellular matrix (ECM), to be attained by neoformation of its structural components1.
The neoformation of ECM’s structural components needs the physiological stimulation of fibroblasts in the regenerative rather than the reparative sense, which requires the involvement of CD44 receptors activating  proteins synthesis and improving the neo formation of reticular collagen, Hyaluronic acid and elastin. Studies demonstrate that CD44 is involved in such a kind of activation by binding 200kDa HA, but not HA with a high molecular weight.2

Biostimulation achieved by hyaluronic acid relies on organisms’ response to a natural compound of the extracellular matrix, instead of a reaction to a foreign body. By stimulating the body’s natural response, rejuvenation in the deeper layers of the skin is achieved.

  1. Maurizio Ceccarelli & Cristiano Curcio, Biostimulation and Biorestructuration of the Skin, The Physiological medical Letter, Vol. 1, Jan 2010, no 2
  2. P H Weigel and B A Baggenstoss, What is special about 200 kDa hyaluronan that activates hyaluronan receptor signaling? Glycobiology, 2017, vol. 27, no. 9, 868–877


To access this page, please click YES if you are a healthcare professional.
If you are not a healthcare professional, select NO to exit.