HYALURONIC ACID

WHAT is it?

It is an endogenous molecule, which is found in many organisms and is considered to be highly important for the evolution of species.

Where does it
come from?

For many years, this polysaccharide was produced via extraction processes from tissue of animal origin. More recently, thanks to the research carried out in our laboratories, a bacteria from the Streptococcus equi family was “trained” to produce hyaluronic acid of the high standard of quality required for medical use, via a fermentation process.

The regenerative power of
Hyaluronic Acid

It is well known that hyaluronic acid (HA), particularly at a high molecular weight, is very hydrophilic, contributing to its excellent skin hydrating capabilities.1  Due to its high affinity for water, HA therefore plays an integral role in maintenance and regulation of the homeostasis of intradermic water. Moreover, it has been demonstrated that HMW* HA protects cells and ECM components from free radicals’ damages.2
HA performs several biological actions in addition to being hydrophilic. These actions vary according to molecular weight.3 Research shows that at a lower molecular weight  in the range of 200kD HA is characterized by its growth activating and reparative properties.
When evaluated the effect on proliferative activity in cultures of cutaneous fibroblasts and keratinocytes, results demonstrated that only HA at a MW of 200 kDa induced the strongest proliferative effect on both cell types4.
* High Molecular Weight

STRUCTURAL role of HA

Protection

Hydration

Detoxification

BIOLOGICAL role of HA

Cell proliferation

Neo-Synthesis of matrix

  1. Narurkar VA, Fabi SG, Bucay VW et al. A New Approach in Topical Hyaluronic Acid: Going Beyond Instant Benefits to Restore Epidermal HA Homeostasis. Journal of Drugs in Dermatology. 2016: 15; 1 (Supp. 2)
  2. Hyaluronan-mediated protective effect against cell damage caused by enzymatically produced hydroxyl (OH.) radicals is dependent on hyaluronan molecular mass. Presti D, Scott JE.Cell Biochem Funct. 1994 Dec;12(4):281-8
  3. Cooper CA, Brown KK, Meletis CD, Zabriskie N. Inflammation and hyaluronic acid. Altern Complement Therapies 2008;14:78e84
  4. Wohlrab J, Wohlrab D, Neubert RH. Comparison of noncross-linked and cross-linked hyaluronic acid with regard to efficacy of the proliferative activity of cutaneous fibroblasts and keratinocytes in vitro. J Cosmet Dermatol. 2013; 12(1):36-40

THIS PAGE IS INTENDED ONLY FOR HEALTHCARE PROFESSIONALS

To access this page, please click YES if you are a healthcare professional.
If you are not a healthcare professional, select NO to exit.